FDA Information
Cyanocobalamin has been approved by the US Food and Drug Administration. The tablet form of cyanocobalamin is available over-the-counter.
History as a treatment for anemia:
B12 deficiency is the cause of several forms of anemia. The treatment for this disease was first devised by William Murphy who bled dogs to make them anemic and then fed them various substances to see what (if anything) would make them healthy again. He discovered that ingesting large amounts of liver seemed to cure the disease. George Minot and George Whipple then set about to chemically isolate the curative substance and ultimately were able to isolate vitamin B12 from the liver. For this, all three shared the 1934 Nobel Prize in Medicine.
The chemical structure of the molecule was determined by Dorothy Crowfoot Hodgkin and her team in 1956, based on crystallographic data.
Please visit the official site of the FDA for further information.
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